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M94A2892.TXT
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1994-10-25
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Document 2892
DOCN M94A2892
TI Xerophthalmia in HIV-disease.
DT 9412
AU Libera S; Geier SA; Klauss V; Goebel FD; Medizinische Poliklinik and
Augenklinik der LMU, Munich, Germany.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):200 (abstract no. PB0229). Unique
Identifier : AIDSLINE ICA10/94369683
AB OBJECTIVE: The purpose of this study was to look for an association of
severity of HIV disease with decreased tear production in a controlled
setting. PATIENTS AND METHODS: 72 patients (144 eyes) and 20 age- and
sex-matched controls (40 eyes) were prospectively studies. Tear
production was measured applying the Schirmer test (measured in mm after
5 minutes), and patients were staged according to severity of
HIV-disease. RESULTS: The relative frequency of eyes with significantly
decreased tear production (< 9 mm = mean-value of the normal
controls--2xSD) was 23.6% in all 144 eyes. The relative frequency of
significantly decreased tear production did not differ (p = 0.52)
between eyes of patients with asymptomatic HIV infection (35.7%), LAS or
AIDS-related complex (21.4%), and AIDS (24.1%). Furthermore, mean tear
production did not differ (p = 0.32) between eyes of patients with
asymptomatic HIV infection, LAS or ARC, and AIDS. CONCLUSION: Our data
show that xerophthalmia occurs in about 20% to 25% of patients with HIV
infection. This increased frequency is not related to the severity of
HIV disease. The possibility of an autoimmune-like pathogenesis of
abnormalities of tear production in patients with HIV infection should
be intensively discussed.
DE Acquired Immunodeficiency Syndrome/COMPLICATIONS AIDS-Related
Complex/COMPLICATIONS Human HIV Infections/*COMPLICATIONS Prevalence
Prospective Studies Xerophthalmia/*COMPLICATIONS/DIAGNOSIS/EPIDEMIOLOGY
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).